How does tramadol interact with beta-blockers in hypertensive patients and what are the potential risks of combined therapy?
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What specific concerns arise with tramadol use in patients with adrenal insufficiency and how should treatment be adjusted?
How does tramadol impact vision and what visual disturbances, such as blurriness or light sensitivity, have been reported?
Can tramadol be used for pain relief in patients recovering from joint replacement surgeries and how does it compare to other analgesics?
How does tramadol influence the risk of gastrointestinal ulcers compared to other opioids and what protective strategies can reduce this risk?
Can tramadol cause or worsen tinnitus or hearing loss and what mechanisms might explain these auditory side effects?
How does tramadol affect thermoregulation in patients with fever or hypothermia and could it exacerbate or improve temperature regulation issues?
Can tramadol be safely used in patients undergoing dialysis and what dosage adjustments or monitoring are necessary?
How does tramadol compare to buprenorphine in treating moderate to severe pain and what are the benefits or drawbacks of each?
Can tramadol manage pain in patients with peripheral artery disease and what considerations are necessary for safe and effective use?