Why is drinking grapefruit juice while taking amlodipine discouraged, and what specific interactions between the juice and medication could result in adverse effects or reduced efficacy?
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Why is drinking grapefruit juice while taking amlodipine discouraged, and what specific interactions between the juice and medication could result in adverse effects or reduced efficacy?
Grapefruit juice inhibits CYP3A4, an enzyme that metabolizes amlodipine. This can increase the drug’s concentration in the bloodstream, potentially leading to severe side effects.