Aspirin inhibits both COX-1 and COX-2 enzymes, reducing pain and inflammation but increasing gastric risks. Ibuprofen targets the same enzymes but is less harsh on the stomach.

Aspirin can cause gastrointestinal issues and is not recommended for those with clotting disorders. Ibuprofen is safer for short-term use, but can affect kidney function and blood pressure.

Ibuprofen often provides quicker relief from pain and inflammation compared to aspirin and has a lower risk of severe gastrointestinal side effects. However, it can impact renal function with long-term use.