Methyldopa and antipsychotics can both increase prolactin levels, potentially leading to side effects like galactorrhea. Monitoring is advised.

Methyldopa, combined with antipsychotic medications, may enhance sedative effects and increase the risk of orthostatic hypotension; close monitoring is necessary.

Combining methyldopa with antipsychotics in hypertensive patients could heighten the risk of central nervous system depression and cardiovascular side effects.