How does clomiphene citrate work to increase testosterone levels in men with hypogonadism, and what physiological pathways are involved in this process?
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How does clomiphene citrate work to increase testosterone levels in men with hypogonadism, and what physiological pathways are involved in this process?
Clomiphene citrate boosts testosterone in men by blocking estrogen receptors in the brain, prompting increased secretion of LH and FSH, which stimulates testicular production of testosterone.
Clomiphene citrate treats male hypogonadism by blocking estrogen receptors in the brain, thus increasing GnRH secretion, which stimulates the pituitary to release LH and FSH; these hormones enhance testosterone production by the testes.